Studies on ketene and its derivatives. CXII. Reaction of ketene with Schiff bases to give .ALPHA.-unsubstituted .BETA.-lactams.
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چکیده
منابع مشابه
synthesis and characterization of some macrocyclic schiff bases
ماکروسیکلهای شیف باز از اهمیت زیادی در شیمی آلی و دارویی برخوردار می باشند. این ماکروسیکلها با دارابودن گروه های مناسب در مکانهای مناسب می توانند فلزاتی مثل مس، نیکل و ... را در حفره های خود به دام انداخته، کمپلکسهای پایدار تولید نمایند. در این پایان نامه ابتدا یک دی آلدئید آروماتیک از گلیسیرین تهیه می شود و در مرحله بعدی واکنش با دی آمینهای آروماتیک و یا آلیفاتیک در رقتهای بسیار زیاد منجر به ت...
15 صفحه اولAction of Ketene on Gonadotropic Hormones*
Ketene has been found to be a highly specific,acetylating agent for aqueous solution of proteins. It reacts only with amino, thiol, and phenolic hydroxy groups (1). Several investigators (24) have shown that the primary amino groups react most rapidly, while the hydroxy groups of tyrosine are acetylated at a much slower rate. The hydroxy groups in carbohydrate radicals of the protein molecule d...
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A simple apparatus for the preparation of ketene (CH,--C =O) from acetone vapor is described by Ott, Schr6ter, and Packendofff (1). A more rigid and convenient apparatus has been designed and used by the writer (Fig. 1). Pyrex glass used in both the filamentsupport and bulb reduces the possibility of cracking or breaking. The removable filament-support makes it possible to replace the filament ...
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We report catalytic, enantioselective [4 + 2]-cycloadditions of o-quinones with ketene enolates (derived from readily available acid chlorides) using cinchona alkaloid derivatives as catalysts to produce products in high enantiomeric excess (ee) and good to excellent yields. The thermodynamic driving force for these reactions is due in part to the restoration of aromaticity to the products. The...
متن کاملOne Pot Synthesis of Alpha-Aminonitrile and Alpha-Amino Acid From Schiff Bases
Addition of Potassium cyanide to a mixture of Schiff base and lithium perchlorate afforded a-aminonitriles in high yields. Addition of potassium cyanide to a methanolic solution of Schiff base and phosphoric acid afforded a-aminonitriles. When the reaction mixture was refluxed it gave a-amino acids in high yields.
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1983
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.31.538